TTD | Drug: D09FAO

Drug General Information
Drug ID	D09FAO
Former ID	DIB020654
Drug Name	PD 154740
Synonyms	PD-154740; PD154740
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541094]
Structure		Download 2D MOL
Formula	C32H47N3O5
InChI	InChI=1S/C32H47N3O5/c1-31(2,3)40-30(39)34-27(23-25-17-11-9-12-18-25)28(37)35-29(38)32(4,24-26-19-13-10-14-20-26)33-21-15-7-5-6-8-16-22-36/h9-14,17-20,27,33,36H,5-8,15-16,21-24H2,1-4H3,(H,34,39)(H,35,37,38)/t27-,32+/m0/s1
InChIKey	LLSVPRQAIHTVBK-QVWWMRLHSA-N
PubChem Compound ID	190945
PubChem Substance ID	33512199, 75046353, 103850351, 113449829, 117550573, 135168535, 178102391
Target and Pathway
Target(s)	Nigral tachykinin NK(3) receptor	Target Info	Antagonist	[533591]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541094	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5766).
Ref 533591	Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokinin3 receptor. Mol Pharmacol. 1995 Oct;48(4):711-6.

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Drug Information