Drug Information

Drug General Information
Drug ID
D0T5OX
Former ID
DAP000264
Drug Name
Remifentanil
Synonyms
Remifentanyl; Ultiva; GI 87084B; GI 87084X; GI87084B; Remifentanil (INN); Remifentanil [INN:BAN]; Ultiva (TN); Methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate; 1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester; 3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester; 4-carboxy-4-(n-phenylpropionamido)-1-piperidinepropionic acid dimethyl ester
Drug Type
Small molecular drug
Indication General anesthesia [ICD9: 338; ICD10:R20.0] Approved [538551], [542313]
Therapeutic Class
Hypnotics and Sedatives
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C20H28N2O5
InChI
InChI=1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3
InChIKey
ZTVQQQVZCWLTDF-UHFFFAOYSA-N
CAS Number
CAS 132875-61-7
PubChem Compound ID
60815
PubChem Substance ID
10221, 6595876, 7980495, 8187072, 14902224, 43118154, 46504538, 50016966, 57314129, 76410936, 85209930, 93166187, 96025159, 103267286, 104321713, 117552936, 124403616, 129954253, 134224470, 134337578, 135049469, 137003165, 139212458, 160964238, 164814940, 175267741, 178103866, 179149818, 226422640, 250135003
SuperDrug ATC ID
N01AH06
SuperDrug CAS ID
cas=132875617
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [536965]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 538551FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020630.
Ref 542313(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7292).
Ref 536965The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. Pain. 2009 Jan;141(1-2):88-96. Epub 2008 Dec 5.

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