Drug Information

Drug General Information
Drug ID
D0N1YW
Former ID
DNC005783
Drug Name
GNF-PF-2322
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527713]
Structure
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2D MOL

3D MOL
Formula
C26H26N4O3
Canonical SMILES
CCN1CCN(CC1)C2=NC3=C(C=C(C=C3)NC(=O)C4=CC(=O)C5=CC=CC=C<br />5O4)C(=C2)C
InChI
1S/C26H26N4O3/c1-3-29-10-12-30(13-11-29)25-14-17(2)20-15-18(8-9-21(20)28-25)27-26(32)24-16-22(31)19-6-4-5-7-23(19)33-24/h4-9,14-16H,3,10-13H2,1-2H3,(H,27,32)
InChIKey
GDOKGIIKPLGRMR-UHFFFAOYSA-N
PubChem Compound ID
44403736
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Inhibitor [527713]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527713J Med Chem. 2005 Sep 8;48(18):5684-97.6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.
Ref 527713J Med Chem. 2005 Sep 8;48(18):5684-97.6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.

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