Drug General Information
Drug ID
D01GEO
Former ID
DNC001422
Drug Name
Telomestatin
Drug Type
Small molecular drug
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Investigative [537114]
Company
Geron Corp
Structure
Download
2D MOL

3D MOL

Formula
C26H14N8O7S
Canonical SMILES
CC1=C2C3=NC(=C(O3)C)C4=NC(=CO4)C5=NC(=CO5)C6=NC(=CO6)C7<br />=NC(=CO7)C8=NC(=CO8)C9=NC(CS9)C(=N2)O1
InChI
1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,16H,8H2,1-2H3
InChIKey
YVSQVYZBDXIXCC-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Telomerase reverse transcriptase Target Info Inhibitor [537114]
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
Regulation of Telomerase
IL2 signaling events mediated by PI3K
Regulation of nuclear beta catenin signaling and target gene transcription
HIF-1-alpha transcription factor network
Reactome Formation of the beta-catenin:TCF transactivating complex
References
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.

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