TTD | Drug: D08MJE

Drug General Information
Drug ID	D08MJE
Former ID	DNC010686
Drug Name	(R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530771]
Structure		Download 2D MOL 3D MOL
Formula	C22H19NO3
Canonical SMILES	C1=CC=C(C=C1)C=CCC(C(=O)O)NC(=O)C2=CC3=CC=CC=C3C=C2
InChI	1S/C22H19NO3/c24-21(19-14-13-17-10-4-5-11-18(17)15-19)23-20(22(25)26)12-6-9-16-7-2-1-3-8-16/h1-11,13-15,20H,12H2,(H,23,24)(H,25,26)/b9-6+/t20-/m1/s1
InChIKey	OOTIJYFZZMIZHN-AQDCRGGLSA-N
PubChem Compound ID	45100499
Target and Pathway
Target(s)	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Target Info	Inhibitor	[530771]
KEGG Pathway	RIG-I-like receptor signaling pathway
Pathway Interaction Database	p73 transcription factor network
	C-MYC pathway
	PDGFR-beta signaling pathway
	p53 pathway
Reactome	ISG15 antiviral mechanism
Reactome	Negative regulators of RIG-I/MDA5 signaling
WikiPathways	ISG15 antiviral mechanism
WikiPathways	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
References
Ref 530771	Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. Epub 2010 Feb 14.Structure-based design of novel human Pin1 inhibitors (II).
Ref 530771	Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. Epub 2010 Feb 14.Structure-based design of novel human Pin1 inhibitors (II).

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Drug Information