TTD | Drug: D07FLX

Drug General Information
Drug ID	D07FLX
Former ID	DIB018778
Drug Name	AGN 191976
Synonyms	AGN-191976; AGN191976
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541320]
Structure		Download 2D MOL
Formula	C21H34O6
InChI	InChI=1S/C21H34O6/c1-2-3-6-9-15(22)12-13-17-16(10-7-4-5-8-11-20(23)24)18-14-19(17)27-21(25)26-18/h4,7,15-19,22H,2-3,5-6,8-14H2,1H3,(H,23,24)/b7-4-/t15-,16+,17+,18-,19+/m0/s1
InChIKey	CVQLYMOSZQTFDP-NFUXFLSFSA-N
PubChem Compound ID	73755173
PubChem Substance ID	178102692
Target and Pathway
Target(s)	Thromboxane A2 receptor	Target Info	Agonist	[534256]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
	Thromboxane signalling through TP receptor
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541320	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6071).
Ref 534256	Evidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alpha. Br J Pharmacol. 1996 Mar;117(6):1171-80.

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Drug Information