Drug Information

Drug General Information
Drug ID
D06NDR
Former ID
DNC007388
Drug Name
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528653]
Structure
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2D MOL

3D MOL
Formula
C13H19ClN2O3
Canonical SMILES
CCCCC(C(=O)NO)NOCC1=CC=C(C=C1)Cl
InChI
1S/C13H19ClN2O3/c1-2-3-4-12(13(17)15-18)16-19-9-10-5-7-11(14)8-6-10/h5-8,12,16,18H,2-4,9H2,1H3,(H,15,17)
InChIKey
SUZRJMQBDIHWSQ-UHFFFAOYSA-N
PubChem Compound ID
44423687
Target and Pathway
Target(s) Carbonic anhydrase I Target Info Inhibitor [528653]
Carbonic anhydrase IX Target Info Inhibitor [528653]
Carbonic anhydrase II Target Info Inhibitor [528653]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 528653Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates.
Ref 528653Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates.

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