Drug Information

Drug General Information
Drug ID
D0U2QT
Former ID
DIB020986
Drug Name
Src kinase inhibitor I
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529039]
Structure
Download
2D MOL
Formula
C22H19N3O3
InChI
InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
InChIKey
DMWVGXGXHPOEPT-UHFFFAOYSA-N
PubChem Compound ID
1474853
PubChem Substance ID
1827795, 3198712, 5468232, 8626979, 11125821, 14828959, 25784849, 26759557, 47601276, 47972531, 53800522, 78350619, 85787188, 88073340, 92281023, 99302779, 103309289, 103992967, 106898168, 110470442, 125446115, 127757691, 135698368, 138256740, 142059904, 162248683, 162447574, 163687298, 164840392, 175607438, 178102664, 179158179, 187071854, 204359774, 208264743, 208265649, 223443689, 223490225, 223912954, 227603818, 252125376, 252157422, 252266743, 252451192
Target and Pathway
Target(s) mRNA of human RIP2 Target Info Inhibitor [529039]
KEGG Pathway NOD-like receptor signaling pathway
Neurotrophin signaling pathway
Shigellosis
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database Canonical NF-kappaB pathway
IL12-mediated signaling events
p75(NTR)-mediated signaling
Reactome NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 signaling
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
WikiPathways TCR Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Apoptosis-related network due to altered Notch3 in ovarian cancer
MAP kinase activation in TLR cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Signalling by NGF
TCR signaling
Interleukin-1 signaling
NOD pathway
References
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.
Ref 529039Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update.

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