Drug General Information
Drug ID
D0J5KF
Former ID
DAP000295
Drug Name
Granisetron
Synonyms
BRL-43694; Kytril (TN); Granisetron (USAN/INN); 1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide; 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
Drug Type
Small molecular drug
Indication Nausea and vomiting associated with chemotherapy [ICD10:R11] Approved [551871]
Therapeutic Class
Antiemetics
Company
Roche Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C18H24N4O
InChI
InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12?,13-,14+
InChIKey
MFWNKCLOYSRHCJ-AGUYFDCRSA-N
CAS Number
CAS 109889-09-0
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
A04AA02
SuperDrug CAS ID
cas=109889090
Target and Pathway
Target(s) 5-Hydroxytryptamine 3 receptor Target Info Antagonist [536290], [537932]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536290New approaches to chemotherapy-induced nausea and vomiting: from neuropharmacology to clinical investigations. Cancer J. 2006 Sep-Oct;12(5):341-7.
Ref 537932Reduction of rectal sensitivity and post-prandial motility by granisetron, a 5 HT3-receptor antagonist, in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 1993 Apr;7(2):175-80.

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