Drug Information

Drug General Information
Drug ID
D0T0JU
Former ID
DIB021208
Drug Name
waixenicin A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541500]
Structure
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2D MOL
Formula
C26H36O7
InChI
InChI=1S/C26H36O7/c1-16-8-7-9-18(3)25-22(12-10-16)23(15-31-26(25)33-21(6)29)24(32-20(5)28)13-11-17(2)14-30-19(4)27/h8,11,15,22,24-26H,3,7,9-10,12-14H2,1-2,4-6H3/b16-8-,17-11+/t22-,24+,25+,26-/m1/s1
InChIKey
DCZJIZRGTZFSQY-JQIWXNGPSA-N
PubChem Compound ID
73755210
PubChem Substance ID
178102977
Target and Pathway
Target(s) TRPM7 Target Info Blocker (channel blocker) [531626]
References
Ref 541500(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6359).
Ref 531626Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. J Biol Chem. 2011 Nov 11;286(45):39328-35.

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