| Drug General Information |
| Drug ID |
D0R2TM
|
| Former ID |
DNC003686
|
| Drug Name |
BALANOL
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Terminated |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C28H26N2O10
|
| InChI |
InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
|
| InChIKey |
XYUFCXJZFZPEJD-XMSQKQJNSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7886051, 8032894, 11041327, 14763739, 14837260, 39320290, 48110651, 48334706, 50715651, 87544375, 87544377, 103252142, 113870323, 118043174, 127319915, 127319916, 127319917, 127319918, 127319919, 127319920, 127319921, 127319922, 134340891, 137252596, 162255238, 179247016, 226443673, 241113714, 249565822, 252345375
|
| Target and Pathway |
| Target(s) |
mRNA of PKC-epsilon |
Target Info |
Inhibitor |
[3]
|
|---|
| Casein kinase II, alpha chain |
Target Info |
Inhibitor |
[4]
|
| mRNA of PKC-zeta |
Target Info |
Inhibitor |
[3]
|
| mRNA of PKC-delta |
Target Info |
Inhibitor |
[3]
|
| Protein kinase A |
Target Info |
Inhibitor |
[5]
|
| CAMP-dependent protein kinase type II-beta regulatory chain |
Target Info |
Inhibitor |
[5]
|
| Protein kinase C gamma type |
Target Info |
Inhibitor |
[3]
|
| mRNA of human PKC-eta |
Target Info |
Inhibitor |
[3]
|
| mRNA of PKA Catalytic Subunit C-alpha |
Target Info |
Inhibitor |
[5]
|
| Protein kinase C, alpha type |
Target Info |
Inhibitor |
[3]
|
| Protein kinase C, beta type |
Target Info |
Inhibitor |
[3]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Vascular smooth muscle contraction
|
|
Tight junction
|
|
Fc epsilon RI signaling pathway
|
|
Fc gamma R-mediated phagocytosis
|
|
Inflammatory mediator regulation of TRP channels
|
|
Type II diabetes mellitus
|
|
MicroRNAs in cancerhsa03008:Ribosome biogenesis in eukaryotes
|
|
NF-kappa B signaling pathway
|
|
Wnt signaling pathway
|
|
Adherens junction
|
|
Measles
|
|
Herpes simplex infection
|
|
Epstein-Barr virus infectionhsa04015:Rap1 signaling pathway
|
|
Chemokine signaling pathway
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
Hippo signaling pathway
|
|
Platelet activation
|
|
Insulin signaling pathway
|
|
Type II diabetes mellitushsa04062:Chemokine signaling pathway
|
|
Neurotrophin signaling pathway
|
|
GnRH signaling pathway
|
|
Estrogen signaling pathway
|
|
Type II diabetes mellitushsa04210:Apoptosis
|
|
Insulin signaling pathwayhsa04010:MAPK signaling pathway
|
|
ErbB signaling pathway
|
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
HIF-1 signaling pathway
|
|
Phosphatidylinositol signaling system
|
|
mTOR signaling pathway
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
|
Gap junction
|
|
Natural killer cell mediated cytotoxicity
|
|
Leukocyte transendothelial migration
|
|
Circadian entrainment
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Cholinergic synapse
|
|
Serotonergic synapse
|
|
GABAergic synapse
|
|
Dopaminergic synapse
|
|
Long-term depression
|
|
Insulin secretion
|
|
Melanogenesis
|
|
Thyroid hormone synthesis
|
|
Thyroid hormone signaling pathway
|
|
Oxytocin signaling pathway
|
|
Aldosterone-regulated sodium reabsorption
|
|
Endocrine and other factor-regulated calcium reabsorption
|
|
Salivary secretion
|
|
Gastric acid secretion
|
|
Pancreatic secretion
|
|
Amphetamine addiction
|
|
Morphine addiction
|
|
Vibrio cholerae infection
|
|
African trypanosomiasis
|
|
Amoebiasis
|
|
Hepatitis B
|
|
Pathways in cancer
|
|
Proteoglycans in cancer
|
|
MicroRNAs in cancer
|
|
Glioma
|
|
Non-small cell lung cancer
|
|
Choline metabolism in cancerhsa04270:Vascular smooth muscle contraction
|
|
Inflammatory mediator regulation of TRP channelshsa04010:MAPK signaling pathway
|
|
cAMP signaling pathway
|
|
Oocyte meiosis
|
|
Apoptosis
|
|
Adrenergic signaling in cardiomyocytes
|
|
Hedgehog signaling pathway
|
|
Olfactory transduction
|
|
Taste transduction
|
|
Ovarian steroidogenesis
|
|
Progesterone-mediated oocyte maturation
|
|
Glucagon signaling pathway
|
|
Regulation of lipolysis in adipocytes
|
|
Renin secretion
|
|
Vasopressin-regulated water reabsorption
|
|
Bile secretion
|
|
Parkinson's disease
|
|
Prion diseases
|
|
Cocaine addiction
|
|
Alcoholism
|
|
HTLV-I infection
|
|
Epstein-Barr virus infection
|
|
Viral carcinogenesis
|
|
Dilated cardiomyopathyhsa04010:MAPK signaling pathway
|
|
Pathogenic Escherichia coli infection
|
|
Influenza A
|
|
Choline metabolism in cancerhsa04010:MAPK signaling pathway
|
|
B cell receptor signaling pathway
|
|
Carbohydrate digestion and absorption
|
|
Leishmaniasis
|
|
Choline metabolism in cancer
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
|
Alzheimer disease-amyloid secretase pathway
|
|
Angiogenesis
|
|
Apoptosis signaling pathway
|
|
EGF receptor signaling pathway
|
|
Endothelin signaling pathway
|
|
FGF signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
VEGF signaling pathway
|
|
Wnt signaling pathway
|
|
5HT2 type receptor mediated signaling pathway
|
|
Histamine H1 receptor mediated signaling pathway
|
|
Oxytocin receptor mediated signaling pathway
|
|
Thyrotropin-releasing hormone receptor signaling pathway
|
|
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
|
|
Thyrotropin-releasing hormone receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
|
B cell activation
|
|
CCKR signaling map STP00019:Endothelin signaling pathway
|
|
Hedgehog signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group II pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
|
Transcription regulation by bZIP transcription factor
|
|
5HT1 type receptor mediated signaling pathway
|
|
Beta1 adrenergic receptor signaling pathway
|
|
Beta2 adrenergic receptor signaling pathway
|
|
Histamine H2 receptor mediated signaling pathway
|
|
GABA-B receptor II signaling
|
|
Dopamine receptor mediated signaling pathway
|
|
Enkephalin releaseP00002:Alpha adrenergic receptor signaling pathway
|
|
Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
|
|
Metabotropic glutamate receptor group I pathway
|
|
Enkephalin release
|
|
Nicotine pharmacodynamics pathway
|
|
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
|
|
PDGF signaling pathway
|
|
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Endothelins
|
|
LPA receptor mediated events
|
|
TCR signaling in naï
|
|
LPA4-mediated signaling events
|
|
CDC42 signaling events
|
|
TCR signaling in naï
|
|
Thromboxane A2 receptor signaling
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
|
IL2-mediated signaling events
|
|
PDGFR-beta signaling pathway
|
|
IL8- and CXCR1-mediated signaling events
|
|
Regulation of Ras family activation
|
|
Downstream signaling in naï
|
|
BCR signaling pathway
|
|
Atypical NF-kappaB pathway
|
|
DNA-PK pathway in nonhomologous end joining
|
|
Presenilin action in Notch and Wnt signaling
|
|
E-cadherin signaling in the nascent adherens junction
|
|
Lissencephaly gene (LIS1) in neuronal migration and development
|
|
PDGFR-alpha signaling pathway
|
|
Signaling mediated by p38-alpha and p38-beta
|
|
Alpha-synuclein signalingrhoa_pathway:RhoA signaling pathway
|
|
Insulin Pathway
|
|
Noncanonical Wnt signaling pathway
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
IL1-mediated signaling events
|
|
CXCR4-mediated signaling events
|
|
IGF1 pathway
|
|
TNF receptor signaling pathway
|
|
IL2 signaling events mediated by PI3K
|
|
Ceramide signaling pathway
|
|
p75(NTR)-mediated signaling
|
|
amb2 Integrin signaling
|
|
ErbB1 downstream signaling
|
|
Neurotrophic factor-mediated Trk receptor signaling
|
|
Nephrin/Neph1 signaling in the kidney podocyte
|
|
Insulin-mediated glucose transport
|
|
Regulation of Ras family activationendothelinpathway:Endothelins
|
|
IFN-gamma pathway
|
|
Syndecan-4-mediated signaling events
|
|
IL6-mediated signaling events
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
PAR1-mediated thrombin signaling events
|
|
Syndecan-2-mediated signaling events
|
|
Validated transcriptional targets of TAp63 isoforms
|
|
p53 pathway
|
|
Trk receptor signaling mediated by the MAPK pathway
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
Alpha-synuclein signalingendothelinpathway:Endothelins
|
|
Retinoic acid receptors-mediated signaling
|
|
IL8- and CXCR2-mediated signaling events
|
|
IL8- and CXCR1-mediated signaling eventsendothelinpathway:Endothelins
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytesgmcsf_pathway:GMCSF-mediated signaling events
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
LKB1 signaling events
|
|
SHP2 signaling
|
|
Signaling events mediated by HDAC Class I
|
|
Glucocorticoid receptor regulatory network
|
|
ErbB2/ErbB3 signaling events
|
|
IL3-mediated signaling events
|
|
Syndecan-1-mediated signaling events
|
|
VEGFR1 specific signals
|
|
Calcium signaling in the CD4+ TCR pathway
|
|
Aurora A signaling
|
|
Class I PI3K signaling events mediated by Akt
|
|
Alpha4 beta1 integrin signaling eventsendothelinpathway:Endothelins
|
|
Canonical NF-kappaB pathway
|
|
mTOR signaling pathway
|
|
Ras signaling in the CD4+ TCR pathway
|
|
ATF-2 transcription factor network
|
|
a6b1 and a6b4 Integrin signaling
|
|
Fc-epsilon receptor I signaling in mast cells
|
|
JNK signaling in the CD4+ TCR pathway
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000564:Muscle/Heart ContractionPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Activation of PKC through G protein coupled receptor
|
|
Reactome
|
Effects of PIP2 hydrolysis
|
|
DAG and IP3 signaling
|
|
Role of phospholipids in phagocytosis
|
|
G alpha (z) signalling eventsR-HSA-2514853:Condensation of Prometaphase ChromosomesR-HSA-114604:GPVI-mediated activation cascade
|
|
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
|
|
VEGFR2 mediated cell proliferationR-HSA-111465:Apoptotic cleavage of cellular proteins
|
|
Calmodulin induced events
|
|
G alpha (z) signalling events
|
|
HuR (ELAVL1) binds and stabilizes mRNA
|
|
VEGFR2 mediated cell proliferation
|
|
CLEC7A (Dectin-1) signaling
|
|
Interferon gamma signalingR-HSA-163615:PKA activation
|
|
PKA activation in glucagon signalling
|
|
DARPP-32 events
|
|
Regulation of PLK1 Activity at G2/M Transition
|
|
Loss of Nlp from mitotic centrosomes
|
|
Recruitment of mitotic centrosome proteins and complexes
|
|
Loss of proteins required for interphase microtubule organization?from the centrosome
|
|
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
|
|
Vasopressin regulates renal water homeostasis via Aquaporins
|
|
Hedgehog 'off' state
|
|
Anchoring of the basal body to the plasma membrane
|
|
Factors involved in megakaryocyte development and platelet productionR-HSA-111933:Calmodulin induced events
|
|
Disinhibition of SNARE formation
|
|
Trafficking of GluR2-containing AMPA receptors
|
|
WNT5A-dependent internalization of FZD4
|
|
Response to elevated platelet cytosolic Ca2+R-HSA-114508:Effects of PIP2 hydrolysis
|
|
G alpha (z) signalling eventsR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
|
|
PKA activation
|
|
Regulation of insulin secretion
|
|
VEGFA-VEGFR2 Pathway
|
|
Interleukin-3, 5 and GM-CSF signaling
|
|
Degradation of GLI1 by the proteasome
|
|
Degradation of GLI2 by the proteasome
|
|
CD209 (DC-SIGN) signaling
|
|
MAPK6/MAPK4 signaling
|
|
Gluconeogenesis
|
|
Regulation of KIT signaling
|
|
EGFR Transactivation by Gastrin
|
|
Inactivation, recovery and regulation of the phototransduction cascade
|
|
Syndecan interactions
|
|
Acetylcholine regulates insulin secretion
|
|
Ca2+ pathway
|
|
Depolymerisation of the Nuclear Lamina
|
|
Response to elevated platelet cytosolic Ca2+R-HSA-114516:Disinhibition of SNARE formation
|
|
Activation of NF-kappaB in B cells
|
|
Response to elevated platelet cytosolic Ca2+
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Calcium Regulation in the Cardiac Cell
|
|
Wnt Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
G Protein Signaling Pathways
|
|
Myometrial Relaxation and Contraction Pathways
|
|
Oncostatin M Signaling Pathway
|
|
miRs in Muscle Cell Differentiation
|
|
GPCR downstream signaling
|
|
Effects of PIP2 hydrolysis
|
|
Physiological and Pathological Hypertrophy of the HeartWP2652:Mitotic Prometaphase
|
|
BDNF signaling pathway
|
|
TNF alpha Signaling Pathway
|
|
L1CAM interactionsWP536:Calcium Regulation in the Cardiac Cell
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
MAPK Signaling Pathway
|
|
Signaling by TGF-beta Receptor Complex
|
|
Allograft Rejection
|
|
AGE/RAGE pathway
|
|
Signaling Pathways in Glioblastoma
|
|
IL-1 signaling pathway
|
|
GPVI-mediated activation cascade
|
|
Type II diabetes mellitusWP69:TCR Signaling Pathway
|
|
Type II interferon signaling (IFNG)
|
|
IL-6 signaling pathway
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
DAG and IP3 signaling
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Corticotropin-releasing hormone
|
|
B Cell Receptor Signaling Pathway
|
|
Opioid Signalling
|
|
Apoptotic execution phase
|
|
Type II diabetes mellitusWP706:SIDS Susceptibility Pathways
|
|
Regulation of Water Balance by Renal Aquaporins
|
|
Mitotic G2-G2/M phases
|
|
Integration of energy metabolism
|
|
Factors involved in megakaryocyte development and platelet productionWP536:Calcium Regulation in the Cardiac Cell
|
|
Wnt Signaling Pathway Netpath
|
|
Response to elevated platelet cytosolic Ca2+WP536:Calcium Regulation in the Cardiac Cell
|
|
Effects of PIP2 hydrolysisWP706:SIDS Susceptibility Pathways
|
|
Endochondral Ossification
|
|
IL-3 Signaling Pathway
|
|
Mesodermal Commitment Pathway
|
|
Human Complement System
|
|
Dopamine metabolism
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
SREBP signalling
|
|
Factors involved in megakaryocyte development and platelet production
|
|
Nicotine Activity on Dopaminergic NeuronsWP673:ErbB Signaling Pathway
|
|
Kit receptor signaling pathway
|
|
Transcriptional activation by NRF2
|
|
Cardiac Hypertrophic Response
|
|
Syndecan interactions
|
|
Signaling by SCF-KIT
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Spinal Cord Injury
|
|
Integrated Pancreatic Cancer Pathway
|
|
Pathogenic Escherichia coli infection
|
|
Endothelin Pathways
|
|
Response to elevated platelet cytosolic Ca2+
|
|
TOR SignalingWP536:Calcium Regulation in the Cardiac Cell
|
|
Signaling by the B Cell Receptor (BCR)
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Physiological and Pathological Hypertrophy of the Heart
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8142). |
|---|
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003814) |
|---|
| REF 3 | Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995). |
|---|
| REF 4 | J Med Chem. 1996 Dec 20;39(26):5215-27.Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. |
|---|
| REF 5 | J Med Chem. 2005 Sep 8;48(18):5613-38.Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. |
|---|
