Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0O7LU
|
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| Former ID |
DIB018932
|
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| Drug Name |
AZD3463
|
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| Synonyms |
AZD-3463; CS-1382; HY-15609; KB-154896
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [542681] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H25ClN6O
|
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| InChI |
InChI=1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30)
|
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| InChIKey |
GCYIGMXOIWJGBU-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | mRNA of Insulin-like growth factor 1 receptor | Target Info | Inhibitor | [543490] | |
| ALK tyrosine kinase receptor | Target Info | Inhibitor | [543509] | ||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| FoxO signaling pathway | |||||
| Oocyte meiosis | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| AMPK signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Signaling pathways regulating pluripotency of stem cells | |||||
| Long-term depression | |||||
| Ovarian steroidogenesis | |||||
| Progesterone-mediated oocyte maturation | |||||
| Pathways in cancer | |||||
| Transcriptional misregulation in cancer | |||||
| Proteoglycans in cancer | |||||
| Glioma | |||||
| Prostate cancer | |||||
| Melanomahsa05223:Non-small cell lung cancer | |||||
| WikiPathways | Senescence and Autophagy in Cancer | ||||
| Insulin Signaling | |||||
| Endochondral Ossification | |||||
| Focal Adhesion | |||||
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | |||||
| Apoptosis | |||||
| Signaling Pathways in Glioblastoma | |||||
| TSH signaling pathway | |||||
| MicroRNAs in cardiomyocyte hypertrophyWP2848:Differentiation Pathway | |||||
| References | |||||
| Ref 543490 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1801). | ||||
| Ref 543509 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1839). | ||||
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