Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0DD7N
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| Former ID |
DNC000414
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| Drug Name |
CH4474
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [535881] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C20H24N8O6
|
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| Canonical SMILES |
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CC<br />C(=O)O)C(=O)O.O
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| InChI |
1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1
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| InChIKey |
FPJYMUQSRFJSEW-ZOWNYOTGSA-N
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| CAS Number |
CAS 59-05-2
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10255940, 24278233, 24853414, 24897252, 26719762, 46239541, 46386835, 49681549, 50517770, 57350785, 57653876, 91691137, 92308489, 103828399, 113456622, 117541645, 124658830, 124800364, 134339844, 135122321, 137145255, 152344104, 162178613, 162225145, 164759072, 172080194, 179295900, 224759489, 227460980, 241179861, 242186988, 249828714, 252373058, 252817039
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| ChEBI ID |
ChEBI:44185
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| SuperDrug ATC ID |
L01BA01
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| SuperDrug CAS ID |
cas=000059052
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| Target and Pathway | |||||
| Target(s) | ADAM 17 | Target Info | Inhibitor | [535881] | |
| Pathway Interaction Database | ErbB4 signaling events | ||||
| TNF receptor signaling pathway | |||||
| p75(NTR)-mediated signaling | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Collagen degradation | |||||
| Regulated proteolysis of p75NTR | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 t(7 | |||||
| M1580_K2555) Translocation Mutant | |||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| TNF signaling | |||||
| Growth hormone receptor signaling | |||||
| References | |||||
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