Drug Information

Drug General Information
Drug ID
D03BUD
Former ID
DNC012655
Drug Name
BREMAZOCINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538980]
Structure
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2D MOL

3D MOL
Formula
C20H29NO2
InChI
InChI=1S/C20H29NO2/c1-4-20-9-10-21(13-19(23)7-8-19)17(18(20,2)3)11-14-5-6-15(22)12-16(14)20/h5-6,12,17,22-23H,4,7-11,13H2,1-3H3/t17-,20+/m1/s1
InChIKey
ZDXGFIXMPOUDFF-XLIONFOSSA-N
CAS Number
CAS 75684-07-0
PubChem Compound ID
443406
PubChem Substance ID
13955, 841986, 7980054, 26682718, 36886730, 47359956, 47434905, 50729048, 57404375, 99306988, 117397128, 134223921, 135065081, 135650021, 136284369, 137248643, 198967616, 223439141, 226521142
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [531505]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 538980(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1603).
Ref 531505J Med Chem. 1990 Aug;33(8):2286-96.Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine.

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