| Drug General Information |
| Drug ID |
D08EMG
|
| Former ID |
DNC012717
|
| Drug Name |
(S)APOMORPHINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H17NO2
|
| InChI |
InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m0/s1
|
| InChIKey |
VMWNQDUVQKEIOC-ZDUSSCGKSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
11110737, 24671926, 26088392, 26754246, 35412028, 47252419, 47550611, 47623931, 50322704, 57408699, 57736768, 90451435, 103236763, 103923437, 108667036, 109885511, 126651798, 129497606, 131289772, 134349922, 135266545, 135609359, 138621171, 162517257, 179235808, 225157380, 232597267, 252166497, 252614855
|
| Target and Pathway |
| Target(s) |
Dopamine D1 receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
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cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
|
Gap junction
|
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Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Morphine addiction
|
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Alcoholismhsa04015:Rap1 signaling pathway
|
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Alcoholism
|
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PANTHER Pathway
|
Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward System
|
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Reactome
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Dopamine receptors
|
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G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
|
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G alpha (i) signalling events
|
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WikiPathways
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Hypothetical Network for Drug Addiction
|
|
Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
|
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8285). |
|---|
| REF 2 | J Med Chem. 1990 Jun;33(6):1800-5.Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. |
|---|
