Drug Information

Drug General Information
Drug ID
D0L7MM
Former ID
DNC011185
Drug Name
4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528746]
Structure
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2D MOL

3D MOL
Formula
C17H15NO2
Canonical SMILES
C1=CC=C2C=C(C=CC2=C1)NCC3=CC(=C(C=C3)O)O
InChI
1S/C17H15NO2/c19-16-8-5-12(9-17(16)20)11-18-15-7-6-13-3-1-2-4-14(13)10-15/h1-10,18-20H,11H2
InChIKey
QYMHAOZLKJHVDJ-UHFFFAOYSA-N
PubChem Compound ID
43680262
Target and Pathway
Target(s) Insulin receptor Target Info Inhibitor [528746]
Insulin-like growth factor I receptor Target Info Inhibitor [528746]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorptionhsa04014:Ras signaling pathway
Oocyte meiosis
Endocytosis
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanoma
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathwayP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Pathway Interaction Database Insulin Pathway
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin-mediated glucose transporter_nongenomic_pathway:Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junction
PathWhiz Pathway Insulin Signalling
Leucine Stimulation on Insulin Signaling
Reactome IRS activation
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor recyclingR-HSA-2428928:IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
WikiPathways DNA Damage Response (only ATM dependent)
Insulin Signaling
Nanoparticle triggered autophagic cell death
AGE/RAGE pathway
Signaling by Insulin receptor
Folate Metabolism
Type II diabetes mellitus
Vitamin B12 Metabolism
Selenium Micronutrient Network
AMPK SignalingWP615:Senescence and Autophagy in Cancer
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 528746Eur J Pharmacol. 2007 May 7;562(1-2):1-11. Epub 2007 Feb 3.ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents.
Ref 528746Eur J Pharmacol. 2007 May 7;562(1-2):1-11. Epub 2007 Feb 3.ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents.

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