| Drug General Information |
| Drug ID |
D09SUO
|
| Former ID |
DIB020977
|
| Drug Name |
splitomicin
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C13H10O2
|
| InChI |
InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
|
| InChIKey |
ISFPDBUKMJDAJH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
5614465, 8153240, 11114129, 11121743, 11122223, 11362870, 11365432, 11367994, 11370951, 11370952, 11373595, 11376156, 12015614, 15487777, 24724608, 26752214, 26759555, 29224324, 47662436, 47810888, 50104892, 57322688, 74857037, 81055019, 85788291, 91722326, 92310094, 99301006, 99302526, 99375476, 103092662, 103148024, 103297410, 104308751, 117601689, 121363829, 125333607, 132570953, 134964522, 137468463, 160657168, 162023121, 162248340, 163687300, 163835543, 172089098, 175608088, 176236732, 184021964, 223366898
|
| Target and Pathway |
| Target(s) |
NAD-dependent deacetylase sirtuin-1 |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
FoxO signaling pathway
|
|
AMPK signaling pathway
|
|
Glucagon signaling pathway
|
|
Amphetamine addiction
|
|
MicroRNAs in cancer
|
|
PANTHER Pathway
|
p53 pathway
|
|
Pathway Interaction Database
|
p73 transcription factor network
|
|
Signaling events mediated by HDAC Class III
|
|
E2F transcription factor network
|
|
HIF-2-alpha transcription factor network
|
|
Signaling events mediated by HDAC Class I
|
|
FoxO family signaling
|
|
Regulation of Androgen receptor activity
|
|
Regulation of retinoblastoma protein
|
|
Reactome
|
RORA activates gene expression
|
|
Regulation of HSF1-mediated heat shock response
|
|
Circadian Clock
|
|
WikiPathways
|
Integrated Pancreatic Cancer Pathway
|
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8. |
|---|
| REF 2 | J Med Chem. 2010 Feb 11;53(3):1407-11.Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. |
|---|
