Drug Information

Drug General Information
Drug ID
D0R6BE
Former ID
DIB018405
Drug Name
[3H]S-145
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539281]
Structure
Download
2D MOL
Formula
C20H27NO4S
InChI
InChI=1S/C20H27NO4S/c22-19(23)11-7-2-1-6-10-18-15-12-13-16(14-15)20(18)21-26(24,25)17-8-4-3-5-9-17/h1,3-6,8-9,15-16,18,20-21H,2,7,10-14H2,(H,22,23)/b6-1-/t15-,16+,18+,20+/m1/s1
InChIKey
PWTCIBWRMQFJBC-ZEMKZVSASA-N
PubChem Compound ID
5312138
PubChem Substance ID
7980461, 11056899, 14804433, 39341757, 50064175, 57359523, 79658938, 114157972, 134222649, 135256692, 135650957, 135651201, 172649176, 180371910, 198948282, 198987781, 226694316, 226694317, 242651861
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [526796]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539281(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1984).
Ref 526796Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203.

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