Drug Information

Drug General Information
Drug ID
D0W1PV
Former ID
DNC000239
Drug Name
Apicidin
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [542514]
Structure
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2D MOL

3D MOL
Formula
C34H49N5O6
InChI
InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1
InChIKey
JWOGUUIOCYMBPV-GMFLJSBRSA-N
CAS Number
CAS 183506-66-3
PubChem Compound ID
6918328
PubChem Substance ID
12015044, 14789763, 17194818, 29217489, 43529707, 51866642, 57371887, 95153273, 104056492, 114787790, 131281803, 134339717, 137239012, 164178265, 164835913, 187051797, 226513796
Target and Pathway
Target(s) Histone deacetylase Target Info Inhibitor [535634], [536272], [536509]
References
Ref 542514(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7495).
Ref 535634Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells. Cancer Lett. 2003 Jan 28;189(2):197-206.
Ref 536272Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84.
Ref 536509Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92.

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