Drug General Information
Drug ID	D05SKE
Former ID	DNC006460
Drug Name	6-bromo-3-(pyridin-4-yl)-1H-indole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528040]
Structure		Download 2D MOL 3D MOL
Formula	C13H9BrN2
Canonical SMILES	C1=CC2=C(C=C1Br)NC=C2C3=CC=NC=C3
InChI	1S/C13H9BrN2/c14-10-1-2-11-12(8-16-13(11)7-10)9-3-5-15-6-4-9/h1-8,16H
InChIKey	KLYDZCDPTMADJL-UHFFFAOYSA-N
PubChem Compound ID	44410796
Target and Pathway
Target(s)	Inosine-5'-monophosphate dehydrogenase 2	Target Info	Inhibitor	[528040]
BioCyc Pathway	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Guanosine nucleotides de novo biosynthesis
	Superpathway of purine nucleotide salvage
	Purine nucleotides de novo biosynthesis
	Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway	Purine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
PANTHER Pathway	De novo purine biosynthesis
Reactome	Purine ribonucleoside monophosphate biosynthesis
References
Ref 528040	Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors.
Ref 528040	Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors.

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