Drug Information

Drug General Information
Drug ID
D02XLC
Former ID
DNC006231
Drug Name
5-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527871]
Structure
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2D MOL

3D MOL
Formula
C15H10N2O2
Canonical SMILES
CC1=C2C(=C3C(=C1)C(=O)NC3=O)C4=CC=CC=C4N2
InChI
1S/C15H10N2O2/c1-7-6-9-12(15(19)17-14(9)18)11-8-4-2-3-5-10(8)16-13(7)11/h2-6,16H,1H3,(H,17,18,19)
InChIKey
IMEDEXINTFAKNV-UHFFFAOYSA-N
PubChem Compound ID
44407565
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527871]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527871Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.
Ref 527871Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.

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