Drug General Information
Drug ID	D00IGI
Former ID	DNC004971
Drug Name	2-Amino-4-phosphono-butyric acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527336]
Structure		Download 2D MOL 3D MOL
Formula	C4H10NO5P
Canonical SMILES	C(CP(=O)(O)O)C(C(=O)O)N
InChI	1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
InChIKey	DDOQBQRIEWHWBT-UHFFFAOYSA-N
PubChem Compound ID	2207
Target and Pathway
Target(s)	Metabotropic glutamate receptor 8	Target Info	Inhibitor	[527336]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 527336	Bioorg Med Chem Lett. 2005 Jan 17;15(2):349-51.(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors.
Ref 527336	Bioorg Med Chem Lett. 2005 Jan 17;15(2):349-51.(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors.

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