Drug General Information
Drug ID	D0H3MO
Former ID	DIB018057
Drug Name	(-)-norfenfluramine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539374]
Structure		Download 2D MOL
Formula	C10H12F3N
InChI	InChI=1S/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3/t7-/m1/s1
InChIKey	MLBHFBKZUPLWBD-SSDOTTSWSA-N
PubChem Compound ID	12895728
PubChem Substance ID	40619379, 47285836, 47657091, 48404454, 53957517, 103558505, 135650732, 135696252, 136351698, 162846743, 177749718, 227162727, 241066685
Target and Pathway
Target(s)	5-hydroxytryptamine 2B receptor	Target Info	Agonist	[525929]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539374	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 217).
Ref 525929	Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41.

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