Drug Information

Drug General Information
Drug ID
D02WJT
Former ID
DIB018447
Drug Name
1,3-ditolylguanidine
Synonyms
Di-o-tolylguanidine; 1,3-Di-o-tolylguanidine; DOTG
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541790]
Structure
Download
2D MOL

3D MOL
Formula
C15H17N3
InChI
InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
InChIKey
OPNUROKCUBTKLF-UHFFFAOYSA-N
PubChem Compound ID
7333
PubChem Substance ID
67379, 421771, 608776, 5345628, 10538891, 11082497, 11113733, 11408506, 15245918, 24852467, 26751918, 29226199, 47217104, 47960055, 48417003, 49974694, 57264422, 57324125, 80796261, 85085712, 85788117, 87567542, 88836001, 95613214, 103186197, 103917675, 103922363, 104231736, 104314644, 117406144, 117406145, 124582153, 124955039, 125248765, 126678594, 128843064, 131342556, 134341179, 134973014, 135377911, 135562599, 135697791, 137013863, 137103439, 137237355, 142445880, 143432249, 144207910, 151979930, 152055630
Target and Pathway
Target(s) sigma2 Target Info Agonist [528020]
Sigma(1)-type opioid receptor Target Info Agonist [528020]
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 541790(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6684).
Ref 528020Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8.

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