Drug Information

Drug General Information
Drug ID
D01PGU
Former ID
DNC000031
Drug Name
15-deoxy-Delta(12, 14)-prostaglandin J(2)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539754]
Structure
Download
2D MOL

3D MOL
Formula
C20H28O3
InChI
InChI=1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
InChIKey
VHRUMKCAEVRUBK-GODQJPCRSA-N
PubChem Compound ID
5311211
PubChem Substance ID
616280, 841874, 4265965, 7979704, 11056342, 12015428, 14718416, 14874531, 17395716, 26754842, 26754843, 26754844, 26754845, 26759405, 39340919, 47810521, 47885180, 47959481, 50110801, 53786796, 53790973, 56314447, 57359391, 80464931, 85787434, 92309777, 99300691, 99302209, 103640339, 104046458, 104115764, 114155556, 118046117, 126525348, 135651375, 143343420, 144229231, 163687448, 179205589, 184568145, 229217035, 241375873, 249617533, 252156430, 252363988, 252455501, 252457386, 252457388
Target and Pathway
Target(s) Peroxisome proliferator activated receptor gamma Target Info Agonist [535698]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear Receptors
References
Ref 539754(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2692).
Ref 535698Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. Int J Cancer. 2003 May 1;104(5):597-602.

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