Drug Information

Drug General Information
Drug ID
D0XU7M
Former ID
DNC006028
Drug Name
NSC-663284
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527791]
Structure
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2D MOL

3D MOL
Formula
C15H16ClN3O3
Canonical SMILES
C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
InChI
1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChIKey
BMKPVDQDJQWBPD-UHFFFAOYSA-N
PubChem Compound ID
379077
Target and Pathway
Target(s) M-phase inducer phosphatase 3 Target Info Inhibitor [527791]
KEGG Pathway Cell cycle
Oocyte meiosis
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
PANTHER Pathway p53 pathway
Pathway Interaction Database ATR signaling pathway
ATM pathway
PLK1 signaling events
PLK3 signaling events
Reactome Polo-like kinase mediated events
Cyclin B2 mediated events
Activation of ATR in response to replication stress
RHO GTPases activate PKNs
Cyclin A/B1 associated events during G2/M transition
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways Monoamine Transport
DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Mitotic G2-G2/M phases
Cell Cycle
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
References
Ref 527791Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. Epub 2005 Oct 10.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.
Ref 527791Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. Epub 2005 Oct 10.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.

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