Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0NF6F
|
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| Former ID |
DNC001465
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| Drug Name |
Trichostatin A
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [542035] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C17H22N2O3
|
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| InChI |
InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
|
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| InChIKey |
RTKIYFITIVXBLE-QEQCGCAPSA-N
|
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| CAS Number |
CAS 58880-19-6
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
639194, 830546, 841099, 7890895, 10299571, 12013760, 14709930, 14710659, 14800564, 16291220, 17425541, 17435668, 24844209, 24900542, 26697088, 26755794, 26755795, 36887655, 46371223, 46391613, 46506659, 48409855, 49975235, 50111294, 53790917, 56310830, 56310866, 56310944, 56311019, 56311051, 56311436, 56311486, 56311582, 56311740, 56311744, 56311808, 56312025, 56312066, 56312070, 56312071, 56312281, 56312376, 56312416, 56312510, 56312643, 56312984, 56312986, 56313049, 56313053, 56313217
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| ChEBI ID |
ChEBI:46024
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| Target and Pathway | |||||
| Target(s) | Histone deacetylase | Target Info | Inhibitor | [535661], [536509], [537490] | |
| References | |||||
| Ref 535661 | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. Blood. 2003 May 1;101(9):3451-9. Epub 2003 Jan 2. | ||||
| Ref 536509 | Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. | ||||
| Ref 537490 | Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. Mol Biochem Parasitol. 2009 Jun 16. | ||||
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