Drug Information

Drug General Information
Drug ID
D00TUB
Former ID
DNC011635
Drug Name
2-(4-Amino-phenyl)-8-hydroxy-3H-quinazolin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534774]
Structure
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2D MOL

3D MOL
Formula
C14H11N3O2
Canonical SMILES
C1=CC2=C(C(=C1)O)NC(=NC2=O)C3=CC=C(C=C3)N
InChI
1S/C14H11N3O2/c15-9-6-4-8(5-7-9)13-16-12-10(14(19)17-13)2-1-3-11(12)18/h1-7,18H,15H2,(H,16,17,19)
InChIKey
FNYTYXJFOSRUTI-UHFFFAOYSA-N
PubChem Compound ID
10491078
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [534774]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

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