Drug Information

Drug General Information
Drug ID
D0Z9WK
Former ID
DIB020064
Drug Name
iodoaminopotentidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538745]
Structure
Download
2D MOL
Formula
C26H34IN7O2
InChI
InChI=1S/C26H34IN7O2/c27-23-17-21(8-9-24(23)29)25(35)30-11-12-32-26(33-19-28)31-10-5-15-36-22-7-4-6-20(16-22)18-34-13-2-1-3-14-34/h4,6-9,16-17H,1-3,5,10-15,18,29H2,(H,30,35)(H2,31,32,33)
InChIKey
VJTYCMQYDRXNNY-UHFFFAOYSA-N
PubChem Compound ID
181461
PubChem Substance ID
7979628, 15335833, 33504227, 53693875, 57395748, 85209116, 103269818, 104434585, 135159409, 135650404, 163355666
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [534519]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 538745(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1232).
Ref 534519Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells. Br J Pharmacol. 1997 Nov;122(5):867-74.

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