Drug Information
Drug General Information | |||||
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Drug ID |
D09GJI
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Former ID |
DNC008630
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Drug Name |
7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529625] | ||
Structure |
Download2D MOL |
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Formula |
C18H16N2O
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Canonical SMILES |
CC(C1=CC2=C(C=C1)C3=C(C2)C=C(C=C3)O)N4C=CN=C4
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InChI |
1S/C18H16N2O/c1-12(20-7-6-19-11-20)13-2-4-17-14(8-13)9-15-10-16(21)3-5-18(15)17/h2-8,10-12,21H,9H2,1H3
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InChIKey |
LVWQDZJSHTWZHR-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Cytochrome P450 11B1, mitochondrial | Target Info | Inhibitor | [529625] | |
17 alpha-hydroxylase-C17, 20-lyase | Target Info | Inhibitor | [529625] | ||
PathWhiz Pathway | SteroidogenesisPW000045:Androgen and Estrogen Metabolism | ||||
Steroidogenesis | |||||
WikiPathways | Metapathway biotransformation | ||||
Oxidation by Cytochrome P450 | |||||
Metabolism of steroid hormones and vitamin D | |||||
Corticotropin-releasing hormoneWP702:Metapathway biotransformation | |||||
Steroid Biosynthesis | |||||
Glucocorticoid & Mineralcorticoid Metabolism | |||||
Prostate Cancer | |||||
Phase 1 - Functionalization of compounds | |||||
References | |||||
Ref 529625 | Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. Epub 2008 Jul 9.Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge. | ||||
Ref 529625 | Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. Epub 2008 Jul 9.Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge. |
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