Drug Information
Drug General Information | |||||
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Drug ID |
D01IHM
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Former ID |
DNC004062
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Drug Name |
CI-218872
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [533745] | ||
Structure |
Download2D MOL |
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Formula |
C13H9F3N4
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Canonical SMILES |
CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)C(F)(F)F
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InChI |
1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
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InChIKey |
GUOQUXNJZHGPQF-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [533745] | |
Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [533745] | ||
Gamma-aminobutyric-acid receptor alpha-5 subunit | Target Info | Inhibitor | [531188] | ||
Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [533745] | ||
Gamma-aminobutyric-acid receptor alpha-2 subunit | Target Info | Inhibitor | [531188] | ||
Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [531188] | ||
Gamma-aminobutyric-acid receptor alpha-3 subunit | Target Info | Inhibitor | [531188] | ||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Iron uptake and transport | |||||
References | |||||
Ref 531188 | Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. Epub 2010 Sep 29.Design, synthesis, and subtype selectivity of 3,6-disubstituted |A-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. | ||||
Ref 533745 | J Med Chem. 1994 Dec 23;37(26):4576-80.Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. |
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