Drug Information

Drug General Information
Drug ID
D0G3PI
Former ID
DAP000275
Drug Name
Alitretinoin
Synonyms
ATRA; Aberel; Aberela; Acnavit; Airol; Aknefug; Aknoten; Alitretinoina; Alitretinoine; Alitretinoinum; Atragen; Atralin; Avitoin; Betarretin; Dermairol; Effederm; Eudyna; Lsotretinoin; Nexret; Panretin; Panretyn; Panrexin; REA; Renova; Retacnyl; Retinoate; Retinova; Solage; TRETINON; Toctino; Tretinoin; Tretinoina; Tretinoine; Tretinoino; Tretinoinum; Vesanoid; Vesnaroid; Vitinoin; Aberela [Norway]; Accutane Roche; Acnavit [Denmark]; Alitretinoin [USAN]; Avita Gel; Avitoin [Norway]; Cordes VAS [Germany]; Cordes vas; Effederm [France]; Panretin Gel; Retin A; Retinoic acid; Retionic acid; Trans Retinoic Acid; Tretin M; Tretinoin Zinc Salt; Tretinoin liposome; Vitamin A acid; AGN 100335; AGN 192013; ALRT 1057; BAL4079; LGD 100057; LGD 1057; R 2625; [3H]Retinoic acid; A-Vitaminsyre; AGN-192013; ALRT-1057; AT-RA; Acid, Retinoic; Acid, Vitamin A; Alitretinoin (USAN); Atra-IV; Avita (TN); B-Retinoic acid; BAL-4079; BML2-E05; BML2-E06; Beta-Ra; Beta-Retinoic acid; Epi-aberel; LG-100057; LGD-1057; Panretin (TN); Renova (TN); Retin A (TN); Retin-A; Retin-A Micro; Retisol-A; Ro 1-5488; Salt, Tretinoin Zinc; Stieva-A; Stieva-a Forte; Trans-Retinoic acid; Tretinoin (TN); Tri-Luma; Vesanoid (TN); Zinc Salt, Tretinoin; A-Acido (Argentina); Acid, trans-Retinoic; All-trans-Tretinoin; PDT-002-002; Ro-04-4079; (9cis)-retinoic acid; 9 Cis Retinoic Acid; 9(Z)-Retinoic acid; 9-CIS-RETINOIC ACID; 9-CRA; 9-cis RA; 9-cis Retinoic Acid; 9-cis-RA; 9-cis-Tretinoin; 9C-RA; 9CRA
Drug Type
Small molecular drug
Indication Kaposi's sarcoma [ICD9: 176; ICD10:C46] Approved [536361], [539711]
Therapeutic Class
Anticancer Agents
Company
Ligand Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C20H28O2
InChI
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
InChIKey
SHGAZHPCJJPHSC-ZVCIMWCZSA-N
CAS Number
CAS 5300-03-8
PubChem Compound ID
449171
PubChem Substance ID
509159, 584816, 838980, 3718107, 7978614, 8026464, 10300319, 11528315, 12014910, 14898408, 17396485, 17396973, 17486479, 22391507, 24702085, 24899373, 25622044, 25641192, 26681478, 26718599, 26755227, 26755228, 26755229, 26755230, 36890827, 46507356, 47811003, 47885624, 47885625, 50087219, 50110876, 50110877, 50110878, 53790163, 53801213, 56310968, 56313931, 56313962, 57288659, 57404908, 57571034, 75174291, 85240518, 85279329, 85788016, 87219231, 90451653, 92309911, 99300825, 99302343
ChEBI ID
ChEBI:50648
SuperDrug ATC ID
D11AH04; L01XX22
SuperDrug CAS ID
cas=005300038
Target and Pathway
Target(s) Retinoic acid receptor gamma Target Info Modulator [536652]
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Mesodermal Commitment Pathway
Endoderm Differentiation
Nuclear Receptors
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 539711(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2645).
Ref 536652Alitretinoin: a comprehensive review. Expert Opin Investig Drugs. 2008 Mar;17(3):437-43.

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