TTD | Drug: D0U4WP

Drug General Information
Drug ID	D0U4WP
Former ID	DIB021248
Drug Name	YM44781
Synonyms	YM-44781; YM 44781
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539345]
Structure		Download 2D MOL
Formula	C31H32Cl2FN3O2
InChI	InChI=1S/C31H32Cl2FN3O2/c1-36(30(39)21-6-9-25(34)10-7-21)20-24(22-8-11-27(32)28(33)18-22)12-15-37-16-13-31(14-17-37)26-5-3-2-4-23(26)19-29(38)35-31/h2-11,18,24H,12-17,19-20H2,1H3,(H,35,38)
InChIKey	MIXOPBNZLJBQJH-UHFFFAOYSA-N
PubChem Compound ID	10483085
PubChem Substance ID	15506995, 40610676, 80564218, 135651347, 244621108
Target and Pathway
Target(s)	NK-2 receptor	Target Info	Antagonist	[526310]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539345	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2121).
Ref 526310	Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002 May;65(2):96-102.

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Drug Information