Drug Information

Drug General Information
Drug ID
D05PRS
Former ID
DNC005116
Drug Name
4-Thiocyanato-benzenesulfonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527253]
Structure
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2D MOL

3D MOL
Formula
C7H6N2O2S2
Canonical SMILES
C1=CC(=CC=C1SC#N)S(=O)(=O)N
InChI
1S/C7H6N2O2S2/c8-5-12-6-1-3-7(4-2-6)13(9,10)11/h1-4H,(H2,9,10,11)
InChIKey
JAOXYZVWRQDPGB-UHFFFAOYSA-N
PubChem Compound ID
296284
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [527253]
Carbonic anhydrase Target Info Inhibitor [527253]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 527253Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
Ref 527253Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.

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