Drug General Information
Drug ID	D0H1LK
Former ID	DNC004526
Drug Name	3-(4-Amino-phenyl)-pyrrolidine-2,5-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533480]
Structure		Download 2D MOL 3D MOL
Formula	C10H10N2O2
Canonical SMILES	C1C(C(=O)NC1=O)C2=CC=C(C=C2)N
InChI	1S/C10H10N2O2/c11-7-3-1-6(2-4-7)8-5-9(13)12-10(8)14/h1-4,8H,5,11H2,(H,12,13,14)
InChIKey	AFLGSUFOCCZEEZ-UHFFFAOYSA-N
PubChem Compound ID	161760
Target and Pathway
Target(s)	Cytochrome P450 19	Target Info	Inhibitor	[533480]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Ovarian Infertility Genes
	Metabolism of steroid hormones and vitamin D
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compounds
References
Ref 533480	J Med Chem. 1986 Apr;29(4):520-3.Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione.
Ref 533480	J Med Chem. 1986 Apr;29(4):520-3.Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione.

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