Drug Information

Drug General Information
Drug ID
D05SZG
Former ID
DIB020801
Drug Name
resolvin D1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540557]
Formula
C22H32O5
InChI
InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20-,21-/m0/s1
InChIKey
OIWTWACQMDFHJG-LDOXQWQISA-N
PubChem Compound ID
73755062
PubChem Substance ID
178100762, 178101173, 238151587
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Inhibitor (gating inhibitor) [531183]
FMLP-related receptor I Target Info Agonist [530641]
GPR32 Target Info Agonist [530641]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome TRP channelsR-HSA-416476:G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540557(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3934).
Ref 530641Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5.
Ref 531183Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. Br J Pharmacol. 2010 Oct;161(3):707-20.

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