Drug Information

Drug General Information
Drug ID
D0E5QB
Former ID
DNC011267
Drug Name
Ro-65-7219
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531120]
Structure
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2D MOL

3D MOL
Formula
C37H45NO8
Canonical SMILES
COC1=CC=CC=C1COCCCOC2=CC=C(C=C2)C3C(CNCC3OCC(CO)O)OCC4=<br />CC5=CC=CC=C5C(=C4)OC
InChI
1S/C37H45NO8/c1-41-33-11-6-4-9-29(33)24-43-16-7-17-44-31-14-12-27(13-15-31)37-35(20-38-21-36(37)46-25-30(40)22-39)45-23-26-18-28-8-3-5-10-32(28)34(19-26)42-2/h3-6,8-15,18-19,30,35-40H,7,16-17,20-25H2,1-2H3/t30-,35+,36-,37-/m1/s1
InChIKey
QYBJMSXQFYUZHD-ZLWKXDTISA-N
PubChem Compound ID
52945901
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [531120]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 531120J Med Chem. 2010 Nov 11;53(21):7490-520.Direct renin inhibitors as a new therapy for hypertension.
Ref 531120J Med Chem. 2010 Nov 11;53(21):7490-520.Direct renin inhibitors as a new therapy for hypertension.

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