TTD | Drug: D05WON

Drug General Information
Drug ID	D05WON
Former ID	DIB020920
Drug Name	SB-611812
Synonyms	SB611812
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540464]
Structure		Download 2D MOL
Formula	C17H16Cl3F3N2O3S
InChI	InChI=1S/C17H16Cl3F3N2O3S/c1-25(2)5-6-28-15-9-11(3-4-12(15)18)24-29(26,27)16-13(19)7-10(8-14(16)20)17(21,22)23/h3-4,7-9,24H,5-6H2,1-2H3
InChIKey	UIZHOFJFIOCYLH-UHFFFAOYSA-N
PubChem Compound ID	10278166
PubChem Substance ID	15283185, 22655691, 35449371, 79688025, 103764854, 104142006, 137074987, 140166575, 172918561, 178100510, 223810832, 232255392, 241377115, 243526077, 249691251, 252158261
Target and Pathway
Target(s)	Urotensin II receptor	Target Info	Antagonist	[527752]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 540464	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3531).
Ref 527752	A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker. J Mol Cell Cardiol. 2005 Nov;39(5):785-91. Epub 2005 Sep 19.

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Drug Information