Drug General Information
Drug ID	D06OMD
Former ID	DNC013308
Drug Name	7-(4-methoxypyrimidin-2-yl)-2-methylquinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528793]
Structure		Download 2D MOL 3D MOL
Formula	C15H13N3O
Canonical SMILES	CC1=NC2=C(C=C1)C=CC(=C2)C3=NC=CC(=N3)OC
InChI	1S/C15H13N3O/c1-10-3-4-11-5-6-12(9-13(11)17-10)15-16-8-7-14(18-15)19-2/h3-9H,1-2H3
InChIKey	RMLLQYDXXOIJNH-UHFFFAOYSA-N
PubChem Compound ID	44427382
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[528793]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528793	Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. Epub 2007 Mar 24.Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.
Ref 528793	Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. Epub 2007 Mar 24.Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.

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