Drug Information

Drug General Information
Drug ID
D07WFK
Former ID
DAP000922
Drug Name
Acetohexamide
Synonyms
Acetohexamid; Acetohexamida; Acetohexamidum; Dimelin; Dimelor; Dymelor; Gamadiabet; Hypoglicil; Metaglucina; Minoral; Ordimel; Tsiklamid; Acetohexamide Lilly Brand; Acetohexamide Salvat Brand; Lilly Brand of Acetohexamide; Ord imel; Salvat Brand of Acetohexamide; U 14812; A-178; Acetohexamida [INN-Spanish]; Acetohexamidum [INN-Latin]; Dimelin (antidiabetic); Dymelor (TN); U-14812; Acetohexamide (JP15/USP/INN); Acetohexamide [USAN:INN:BAN:JAN]; N-(p-Acetylbenzenesulfonyl)-N'-cyclohexylurea; N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea; 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea; 1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea; 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea; 3-cyclohexyl-1-(p-acetylphenylsulfonyl)urea; 4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulfonamide; 4-Acetyl-N-[(cyclohexylamino)-carbonyl]benzenesulfonamide; 4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide; 4-acetyl-N-((cyclohexylamino)carbonyl)benzenesulf onamide
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Approved [538241], [541874]
Therapeutic Class
Hypoglycemic Agents
Structure
Download
2D MOL

3D MOL
Formula
C15H20N2O4S
InChI
InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
InChIKey
VGZSUPCWNCWDAN-UHFFFAOYSA-N
CAS Number
CAS 968-81-0
PubChem Compound ID
1989
PubChem Substance ID
9025, 4560832, 7847286, 8144406, 8151368, 10321105, 11110689, 11112460, 11466083, 11467203, 11485866, 15347370, 17390067, 17404651, 24278077, 26752942, 29221177, 46505821, 47216939, 47440426, 47662475, 47810929, 48185152, 48413134, 48415505, 48422764, 48424779, 49698323, 49856121, 50105548, 50105549, 50271749, 53777194, 56463352, 57321086, 57653828, 85083217, 85230885, 85787831, 90341130, 92125175, 92303511, 92307991, 99222786, 103590218, 103913586, 104171099, 104299291, 121360822, 121362846
ChEBI ID
ChEBI:28052
SuperDrug ATC ID
A10BB31
Target and Pathway
Target(s) Sulfonylurea receptor 1 Target Info Modulator
KEGG Pathway ABC transporters
Insulin secretion
Type II diabetes mellitus
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
PathWhiz Pathway Muscle/Heart Contraction
Pancreas Function
Reactome ABC-family proteins mediated transport
Regulation of insulin secretion
WikiPathways Potassium Channels
Integration of energy metabolism
References
Ref 538241FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071893.
Ref 541874(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6793).

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