Drug Information

Drug General Information
Drug ID
D01PJR
Former ID
DAP000517
Drug Name
Tocainide
Synonyms
Taquidil; Tocainida; Tocainidum; Tonocard; Astra W 36095; Tocainida [INN-Spanish]; Tocainidum [INN-Latin]; W-36095; Tocainide (USAN/INN); Tocainide [USAN:BAN:INN]; Alanyl-2,6-xylidide; N-(2,6-dimethylphenyl)alaninamide; (-)-2-Amino-N-(2,6-dimethylphenyl)propanamide; 2-AMINO-N-(2,6-DIMETHYLPHENYL)PROPANAMIDE; 2-Amino-2',6'-propionoxylidide; 2-Amino-N-(2,6-dimethylphenyl)propionamid
Drug Type
Small molecular drug
Indication Ventricular arrhythmias [ICD9: 427.1; ICD10:I47.2] Approved [538501], [542331]
Therapeutic Class
Antiarrhythmic Agents
Structure
Download
2D MOL

3D MOL
Formula
C11H16N2O
InChI
InChI=1S/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14)
InChIKey
BUJAGSGYPOAWEI-UHFFFAOYSA-N
CAS Number
CAS 41708-72-9
PubChem Compound ID
38945
PubChem Substance ID
9351, 6596767, 7980808, 8175799, 11467055, 11468175, 11486810, 14797358, 26719896, 26755668, 34704899, 46386772, 46505385, 47207830, 47647789, 47945105, 48095800, 48170709, 49681729, 49699394, 50025969, 50111018, 50209485, 56313712, 56459344, 57312259, 85788915, 90341559, 92308356, 92714653, 92729958, 103990696, 104234273, 104330445, 117572998, 119526024, 124658847, 124800068, 125536952, 126623963, 127569462, 134337809, 135002146, 135111575, 135251693, 137231400, 142472715, 145355976, 160964390, 162022110
SuperDrug ATC ID
C01BB03
SuperDrug CAS ID
cas=041708729
Target and Pathway
Target(s) E3 ubiquitin protein ligase COP1 Target Info Modulator [556264]
KEGG Pathway p53 signaling pathway
Ubiquitin mediated proteolysis
PANTHER Pathway P53 pathway feedback loops 1
Pathway Interaction Database ATM pathway
Direct p53 effectors
p53 pathway
References
Ref 538501FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018257.
Ref 542331(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7309).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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