TTD | Drug: D05QTT

Drug General Information
Drug ID	D05QTT
Former ID	DIB021040
Drug Name	tetralin_urea analogue (7o)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538808]
Structure		Download 2D MOL
Formula	C26H31ClFN5O
InChI	InChI=1S/C26H31ClFN5O/c1-31-11-13-32(14-12-31)9-2-10-33(26(34)30-22-6-8-25(28)24(27)17-22)23-7-5-20-4-3-19(18-29)15-21(20)16-23/h3-4,6,8,15,17,23H,2,5,7,9-14,16H2,1H3,(H,30,34)
InChIKey	GQGGDNLJDZHJKN-UHFFFAOYSA-N
PubChem Compound ID	11691555
PubChem Substance ID	16795906, 23786059, 42858473, 79618551, 103502648, 104082550, 135651251, 137620531, 139148375, 224018980, 229957285, 245803549
Target and Pathway
Target(s)	Melanin-concentrating hormone receptor 1	Target Info	Antagonist	[528636]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538808	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1319).
Ref 528636	Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1718-21. Epub 2006 Dec 24.

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Drug Information