Drug Information

Drug General Information
Drug ID
D05NZI
Former ID
DNC011905
Drug Name
BRL-26175
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533954]
Structure
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2D MOL

3D MOL
Formula
C23H28ClN3O2
Canonical SMILES
COC1=CC(=C(C=C1C(=O)NC2CC3CCCC(C2)N3CC4=CC=CC=C4)Cl)N
InChI
1S/C23H28ClN3O2/c1-29-22-13-21(25)20(24)12-19(22)23(28)26-16-10-17-8-5-9-18(11-16)27(17)14-15-6-3-2-4-7-15/h2-4,6-7,12-13,16-18H,5,8-11,14,25H2,1H3,(H,26,28)
InChIKey
BUPWFKLTAPZHIE-UHFFFAOYSA-N
PubChem Compound ID
44348012
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [533954]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 533954J Med Chem. 1993 Nov 12;36(23):3707-20.18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.
Ref 533954J Med Chem. 1993 Nov 12;36(23):3707-20.18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.

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