Drug Information

Drug General Information
Drug ID
D0M2MR
Former ID
DAP000522
Drug Name
Gliclazide
Synonyms
Diaikron; Diamicron; Gliclazida; Gliclazidum; Gliklazid; Glimicron; Glyclazide; Nordialex; S 1702; S 852; SE 1702; Diamicron (TN); Dianorm (TN); Gliclazida [INN-Spanish]; Gliclazidum [INN-Latin]; Glimicron (TN); S-1702; S-852; Gliclazide (JAN/INN); Glubitor-OD (TN); Gliclazide [BAN:INN:DCF:JAN]; N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide; N-[(hexahydrocyclopenta[c]pyrrol-2(1H)-ylamino)carbonyl]-4-methylbenzenesulfonamide; N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea; 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea; 1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea; 1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea; 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Approved [549819]
Therapeutic Class
Hypoglycemic Agents
Structure
Download
2D MOL

3D MOL
Formula
C15H21N3O3S
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
InChI
1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
InChIKey
BOVGTQGAOIONJV-UHFFFAOYSA-N
CAS Number
CAS 21187-98-4
PubChem Compound ID
3475
PubChem Substance ID
3206372, 5035155, 7848662, 7979407, 8152209, 10321809, 11342141, 11362324, 11364372, 11366934, 11369496, 11372903, 11374235, 11377658, 11466586, 11467706, 11486292, 11487726, 11491677, 11492413, 11495292, 11533945, 14826273, 24895090, 26612635, 26612723, 26748918, 26748919, 26748920, 29222608, 47656599, 47730748, 48179242, 48179243, 48328563, 48403959, 48416054, 49646130, 49698833, 50061218, 50086570, 50107481, 50107482, 50107483, 50880518, 57321824, 81040947, 81066070, 81093129, 85280584
ChEBI ID
ChEBI:31654
SuperDrug ATC ID
A10BB09
SuperDrug CAS ID
cas=021187984
Target and Pathway
Target(s) Sulfonylurea receptor 1 Target Info Blocker [535269], [535457]
KEGG Pathway ABC transporters
Insulin secretion
Type II diabetes mellitus
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
PathWhiz Pathway Muscle/Heart Contraction
Pancreas Function
Reactome ABC-family proteins mediated transport
Regulation of insulin secretion
WikiPathways Potassium Channels
Integration of energy metabolism
References
Ref 549819Cefradine - FDA approved drug information (drug label) from DailyMed.
Ref 535269Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9.
Ref 535457Pharmacological modulation of K(ATP) channels. Biochem Soc Trans. 2002 Apr;30(2):333-9.

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