Drug Information

Drug General Information
Drug ID
D04ATU
Former ID
DNC005407
Drug Name
8-Amino-6H,11H-indeno[1,2-c]isoquinolin-5-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527674]
Structure
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2D MOL

3D MOL
Formula
C16H12N2O
Canonical SMILES
C1C2=C(C=C(C=C2)N)C3=C1C4=CC=CC=C4C(=O)N3
InChI
1S/C16H12N2O/c17-10-6-5-9-7-14-11-3-1-2-4-12(11)16(19)18-15(14)13(9)8-10/h1-6,8H,7,17H2,(H,18,19)
InChIKey
LQEYAIKMIJUZNT-UHFFFAOYSA-N
PubChem Compound ID
11736764
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527674]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527674J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
Ref 527674J Med Chem. 2005 Aug 11;48(16):5100-3.Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.

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