Drug General Information
Drug ID
D0H8QQ
Former ID
DIB018378
Drug Name
[3H]PGD2
Synonyms
[3H]11-dehydroprostaglandin F2-alpha; [3H]prostaglandin D2; [3H]-PGD2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539191]
Structure
Download
2D MOL
Formula
C20H32O5
InChI
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
InChIKey
BHMBVRSPMRCCGG-OUTUXVNYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Agonist [527971]
Prostaglandin D2 receptor Target Info Agonist [528126]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Small Ligand GPCRs
GPCR downstream signaling
References
Ref 539191(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1891).
Ref 527971On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2. Mol Pharmacol. 2006 Apr;69(4):1441-53. Epub 2006 Jan 17.
Ref 528126GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br J Pharmacol. 2006 Jun;148(3):326-39.

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