Drug Information

Drug General Information
Drug ID
D0RN5A
Former ID
DIB018350
Drug Name
[3H]naloxone
Synonyms
[N-allyl-2,3-3H]naloxone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539038]
Structure
Download
2D MOL
Formula
C19H21NO4
InChI
InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
InChIKey
UZHSEJADLWPNLE-GRGSLBFTSA-N
PubChem Compound ID
5284596
PubChem Substance ID
9461, 113816, 841983, 7980073, 11039368, 11466139, 11467259, 11485797, 14777335, 14924176, 16463984, 25663897, 39317902, 46508816, 47588898, 47588899, 47662178, 47736369, 47959634, 48334383, 48416308, 49698350, 49993151, 50070720, 50104484, 53788675, 56312594, 56312596, 56352924, 57288792, 57359133, 74711224, 85787517, 92309116, 93166268, 96024937, 103170037, 103915330, 124886932, 126688739, 129442197, 134337424, 134974167, 135650684, 135651185, 137001357, 139076562, 144205559, 160964517, 162183031
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Antagonist [533906]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539038(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1676).
Ref 533906Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4.

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