Drug Information

Drug General Information
Drug ID
D0S2GF
Former ID
DIB019126
Drug Name
chlorobenzylidene malononitrile
Synonyms
2-chlorobenzylidene malononitrile; alonitrile; CS gas (lacrimator)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467501]
Structure
Download
2D MOL
Formula
C10H5ClN2
InChI
InChI=1S/C10H5ClN2/c11-10-4-2-1-3-9(10)5-8(6-12)7-13/h1-5H
InChIKey
JJNZXLAFIPKXIG-UHFFFAOYSA-N
PubChem Compound ID
17604
PubChem Substance ID
67440, 232159, 498646, 955197, 3215061, 5229709, 8163190, 10516429, 14772887, 29285333, 48413432, 48422657, 49855269, 57329830, 80028889, 88581417, 97857738, 104342893, 105051443, 117458779, 117465126, 118980115, 123089627, 123106772, 125712204, 126576793, 126727711, 128284315, 134983542, 135363692, 135543561, 137161220, 160793605, 162171828, 162221077, 162281586, 162806586, 163398448, 164795948, 165263289, 172829019, 174528614, 175438477, 176322272, 178100978, 198961152, 204429070, 223487294, 223524802, 224085531
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Activator [529493]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 467501(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4158).
Ref 529493Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):150-6.

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