Drug General Information
Drug ID	D0Z3DW
Former ID	DNC007382
Drug Name	Bis(benzo[b]furan-2-yl)methanone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528608]
Structure		Download 2D MOL 3D MOL
Formula	C17H10O3
Canonical SMILES	C1=CC=C2C(=C1)C=C(O2)C(=O)C3=CC4=CC=CC=C4O3
InChI	1S/C17H10O3/c18-17(15-9-11-5-1-3-7-13(11)19-15)16-10-12-6-2-4-8-14(12)20-16/h1-10H
InChIKey	ZLYFWIZGRHGKMM-UHFFFAOYSA-N
PubChem Compound ID	9179241
Target and Pathway
Target(s)	Beta platelet-derived growth factor receptor	Target Info	Inhibitor	[528608]
	FL cytokine receptor	Target Info	Inhibitor	[528608]
KEGG Pathway	MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	Cytokine-cytokine receptor interaction
	PI3K-Akt signaling pathway
	Focal adhesion
	Gap junction
	Regulation of actin cytoskeleton
	HTLV-I infection
	Pathways in cancer
	MicroRNAs in cancer
	Glioma
	Prostate cancer
	Melanoma
	Central carbon metabolism in cancer
	Choline metabolism in cancerhsa04060:Cytokine-cytokine receptor interaction
	Hematopoietic cell lineage
	Transcriptional misregulation in cancer
	Acute myeloid leukemia
PANTHER Pathway	Angiogenesis
	PDGF signaling pathway
Pathway Interaction Database	Signaling events mediated by PTP1B
	Beta3 integrin cell surface interactions
	S1P3 pathway
	Nectin adhesion pathway
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	PDGFR-beta signaling pathway
	Validated targets of C-MYC transcriptional repression
	PDGF receptor signaling network
Reactome	PIP3 activates AKT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascade
WikiPathways	Regulation of Actin Cytoskeleton
	MAPK Signaling Pathway
	Osteoblast Signaling
	Focal Adhesion
	PIP3 activates AKT signaling
	PDGF Pathway
	Signaling Pathways in Glioblastoma
	Signaling by PDGF
References
Ref 528608	Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. Epub 2006 Dec 12.Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
Ref 528608	Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. Epub 2006 Dec 12.Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.

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