Drug Information

Drug General Information
Drug ID
D03KUH
Former ID
DNC011796
Drug Name
ETICLOPRIDE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543332]
Structure
Download
2D MOL

3D MOL
Formula
C17H25ClN2O3
InChI
InChI=1S/C17H25ClN2O3/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2/h9,12,21H,4-8,10H2,1-3H3,(H,19,22)/t12-/m0/s1
InChIKey
AADCDMQTJNYOSS-LBPRGKRZSA-N
CAS Number
CAS 97612-24-3
PubChem Compound ID
57267
PubChem Substance ID
7979649, 8185140, 11112879, 15373049, 26755017, 43114978, 47359902, 47359903, 47657108, 47731251, 47880096, 48105185, 48179719, 49699374, 49876018, 50110871, 50646253, 53787627, 57313888, 85788896, 99438063, 103168004, 103920793, 104312205, 125092008, 134349092, 134366422, 135027181, 135650243, 142971075, 179151283, 198968683, 226878448
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [530325]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 543332(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 966).
Ref 530325J Med Chem. 1990 Apr;33(4):1155-63.Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.

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